Hydroxocobalamin is a cyanide antidote: among 69 smoke-inhalation victims with suspected cyanide poisoning given 5 g intravenously, 72% survived, 67% of those with confirmed poisoning, with no serious adverse events attributed to it.
emerging — human data exists, and it is thin or contested
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Hydroxocobalamin is a cyanide antidote: among 69 smoke-inhalation victims with suspected cyanide poisoning given 5 g intravenously, 72% survived, 67% of those with confirmed poisoning, with no serious adverse events attributed to it. · pmid:17481777
In healthy heavy smokers, 5 g of intravenous hydroxocobalamin lowered whole-blood cyanide by 59% and turned skin and urine temporarily red, with a transient rise in blood pressure. · pmid:8492341
Proportion of the 2 claims about Hydroxocobalamin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Hydroxocobalamin yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. · pmid 17481777 · 2007
Hydroxocobalamin as a cyanide antidote: safety, efficacy and pharmacokinetics in heavily smoking normal volunteers. · pmid 8492341 · 1993
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.