Des(1-3)IGF-I is a truncated variant of human IGF-I lacking the N-terminal tripeptide Gly-Pro-Glu; it has been isolated from bovine colostrum, human brain and porcine uterus.
preclinical — animal, cell or mechanistic work — not yet about people
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created page created as 'IGF-1 DES' with aliases Des(1-3)IGF-1, Des-IGF-1, Truncated IGF-1 · 2026-09-27 04:00 · somebody
kind set kind set to peptide: palette r1 · 2026-09-27 04:00 · somebody
identity withheld identity not published: PubChem gave no record that proves it is this substance · 2026-09-27 04:00 · somebody
fact added summary: Des(1-3)IGF-I is a truncated variant of human IGF-I lacking the N-terminal tripeptide Gly-Pro-Glu; it has been isolated · 2026-09-27 04:00 · somebody
fact added mechanism: It is generally about ten times more potent than IGF-I on cultured cells because it binds IGF-binding proteins far less, · 2026-09-27 04:00 · somebody
fact added history: A protease able to generate it from IGF-I was found in rat serum and tissues, and its activity rose after hypophysectomy · 2026-09-27 04:00 · somebody
citation added pmid 8930132 cited as preclinical: Review: des(1-3)IGF-I, a truncated form of IGF-I · 2026-09-27 04:00 · somebody
citation added pmid 7561610 cited as preclinical: Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues · 2026-09-27 04:00 · somebody
Negative findings
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