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IGF-1 DES

Des(1-3)IGF-I is a truncated variant of human IGF-I lacking the N-terminal tripeptide Gly-Pro-Glu; it has been isolated from bovine colostrum, human brain and porcine uterus.

What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

    • preclinical
      Claim: Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues standing
    • resolved

    Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues: a further potential site of growth hormone regulation of IGF-I action.

    Yamamoto H, Murphy LJ

    pmid 7561610

    • preclinical
      Claim: Review: des(1-3)IGF-I, a truncated form of IGF-I standing
    • resolved

    Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I.

    Ballard FJ, Wallace JC, Francis GL, Read LC, Tomas FM

    pmid 8930132

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.