Kisspeptin is a central regulator of GnRH release: binding its receptor KISS1R promotes GnRH secretion and so regulates the hypothalamic-pituitary-gonadal axis.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Kisspeptin is a central regulator of GnRH release: binding its receptor KISS1R promotes GnRH secretion and so regulates the hypothalamic-pituitary-gonadal axis. · pmid:35837314
Mechanism
It is a key factor in the initiation of puberty, and mutations in KISS1 or disorders of the kisspeptin/KISS1R system may lead to hypogonadotropic hypogonadism or central precocious puberty. · pmid:35837314
Proportion of the 1 claim about Kisspeptin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Kisspeptin yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction. · pmid 35837314 · 2022
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.