KPV

Summary

KPV is the tripeptide Lys-Pro-Val, the C-terminal residues 11-13 of alpha-melanocyte-stimulating hormone, studied for anti-inflammatory activity. · pmid:18092346

Mechanism

It enters intestinal epithelial and immune cells through the peptide transporter PepT1, and at nanomolar concentrations it inhibited NF-kappaB activation; given in drinking water it reduced colitis in mice. · pmid:18061177

History

In two mouse models of inflammatory bowel disease it hastened recovery and reduced colonic inflammatory infiltrates. · pmid:18092346

Identity

PubChem CID 125672: Msh (11-13), C16H30N4O4, 342.43 g/mol. · pubchem:125672

CAS registry number 67727-97-3. · pubchem:125672

IUPAC name: (2S)-2-[[(2S)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoic acid. · pubchem:125672

Where the evidence actually sits

Proportion of the 2 claims about KPV standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for KPV yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. · pmid 18061177 · 2008
   • Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. · pmid 18092346 · 2008

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.