In the Magpie trial of 10,141 women with pre-eclampsia in 33 countries, magnesium sulphate halved the risk of eclampsia compared with placebo (58% lower) and probably reduced maternal death.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
In the Magpie trial of 10,141 women with pre-eclampsia in 33 countries, magnesium sulphate halved the risk of eclampsia compared with placebo (58% lower) and probably reduced maternal death. · pmid:12057549
A Cochrane review of five trials (6,145 babies) found that magnesium sulphate given to women at risk of preterm birth reduced cerebral palsy in their children (relative risk 0.68). · pmid:19160238
Proportion of the 2 claims about Magnesium sulfate heptahydrate standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Magnesium sulfate heptahydrate yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. · pmid 12057549 · 2002
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. · pmid 19160238 · 2009
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.