MES is one of the Good's buffers; on freezing these buffers tend to become more basic, and MES showed the largest change of the three studied, up to two pH units.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 2 posts naming it, 1 member counted once each.
Summary
MES is one of the Good's buffers; on freezing these buffers tend to become more basic, and MES showed the largest change of the three studied, up to two pH units. · pmid:33271311
Proportion of the 2 claims about MES standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for MES yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Hydrogen ion buffers for biological research. · pmid 5942950 · 1966
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Making good's buffers good for freezing: The acidity changes and their elimination via mixing with sodium phosphate. · pmid 33271311 · 2021
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.