Peptide Atlas · Small molecule

Methylene blue (methylthioninium chloride)

Methylthioninium chloride (methylene blue) is the standard treatment for methemoglobinemia; in 185 cases treated over 24 years at a New York poison center, 98% improved, and adverse effects were reported in 4.9%.

established

provisional
PubChem 6099
2 citations
0 discussions
0 followers
3,7-bis(dimethylamino)phenothiazin-5-ium chloride
Basic Blue 9
MB
Swiss blue
methylthioninium chloride
tetramethylthionine chloride

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Methylene blue (methylthioninium chloride). Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Methylthioninium chloride for methemoglobinemia: 185 poison-center cases, 98% improved	established	pmid 40062661
Methylene blue's mitochondrial electron-carrying action and neuroprotection in animal models	preclinical	pmid 28840449

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.