Peptide Atlas · Small molecule

Methylene blue (methylthioninium chloride)

Methylthioninium chloride (methylene blue) is the standard treatment for methemoglobinemia; in 185 cases treated over 24 years at a New York poison center, 98% improved, and adverse effects were reported in 4.9%.

established

provisional
PubChem 6099
2 citations
0 discussions
0 followers
3,7-bis(dimethylamino)phenothiazin-5-ium chloride
Basic Blue 9
MB
Swiss blue
methylthioninium chloride
tetramethylthionine chloride

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- established
  Claim: Methylthioninium chloride for methemoglobinemia: 185 poison-center cases, 98% improved standing
- resolved
Effectiveness and tolerability of methylthioninium chloride (methylene blue) for the treatment of methemoglobinemia: twenty-four years of experience at a single poison center.
Rothenberg R, Biary R, Hoffman RS
pmid 40062661
- preclinical
  Claim: Methylene blue's mitochondrial electron-carrying action and neuroprotection in animal models standing
- resolved
From Mitochondrial Function to Neuroprotection-an Emerging Role for Methylene Blue.
Tucker D, Lu Y, Zhang Q
pmid 28840449

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.