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Peptide Atlas · Peptide

Mod GRF 1-29

Growth hormone-releasing factor (1-29)NH2 is inactivated in plasma mainly by dipeptidyl peptidase IV, which cleaves it to GRF(3-29)NH2; analogues substituted to resist that enzyme were far more stable.

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What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

    • emerging
      Claim: Nightly GHRH(1-29) injections in healthy elderly men standing
    • resolved

    Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.

    Vittone J, Blackman MR, Busby-Whitehead J, Tsiao C, Stewart KJ, Tobin J, Stevens T, Bellantoni MF, Rogers MA, Baumann G, Roth J, Harman SM, Spencer RG

    pmid 9005976

    • preclinical
      Claim: CJC-1295 described as a tetrasubstituted hGRF(1-29) with an added lysine derivative standing
    • resolved

    Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.

    Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, Paradis V, van Wyk P, Pham K, Bridon DP

    pmid 15817669

    • preclinical
      Claim: Dipeptidyl peptidase IV degrades GRF(1-29)NH2; substituted analogues resist it standing
    • resolved

    The involvement of dipeptidyl peptidase IV in brush-border degradation of GRF(1-29)NH2 by intestinal mucosal cells.

    Bai JP, Chang LL

    pmid 8583376

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

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