Mod GRF 1-29

Summary

Growth hormone-releasing factor (1-29)NH2 is inactivated in plasma mainly by dipeptidyl peptidase IV, which cleaves it to GRF(3-29)NH2; analogues substituted to resist that enzyme were far more stable. · pmid:8583376

History

CJC-1295 was built on a tetrasubstituted form of human GRF(1-29), with an albumin-binding lysine derivative added at the C-terminus. · pmid:15817669

In eleven healthy men aged 64 to 76, six weeks of nightly subcutaneous GHRH (1-29) self-injections were studied for effects on growth hormone, IGF-I, muscle and body composition. · pmid:9005976

Identity

PubChem CID 56841945: L-tyrosyl-D-alanyl-L-alpha-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-glutaminyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-isoleucyl-L-leucyl-L-seryl-L-argininamide, C152H252N44O42, 3367.9 g/mol. · pubchem:56841945

CAS registry number 863288-34-0. · pubchem:56841945

Where the evidence actually sits

Proportion of the 3 claims about Mod GRF 1-29 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Mod GRF 1-29 yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested
   • Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. · pmid 9005976 · 1997
4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. · pmid 15817669 · 2005
   • The involvement of dipeptidyl peptidase IV in brush-border degradation of GRF(1-29)NH2 by intestinal mucosal cells. · pmid 8583376 · 1995

3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.