NA-Semax

Summary

N-terminally acetylated Semax (Ac-Semax) binds copper(II) differently from Semax: its main complex at physiological pH is a distorted CuN3O chromophore rather than the parent peptide's CuN4. · pmid:27586814

Mechanism

Unlike Semax, the acetylated form did not protect SH-SY5Y neuroblastoma cells from copper(II)-induced toxicity, pointing to the free N-terminus as crucial for that protection. · pmid:27586814

Identity

PubChem CID 172638603: N-acetyl semax amidate, C39H54N10O10S, 855.0 g/mol. · pubchem:172638603

CAS registry number 2920938-90-3. · pubchem:172638603

IUPAC name: (4S)-4-[[(2S)-2-acetamido-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[(2S)-2-[[2-[(2S)-2-carbamoylpyrrolidin-1-yl]-2-oxoethyl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid. · pubchem:172638603

Where the evidence actually sits

Proportion of the 1 claim about NA-Semax standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for NA-Semax yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties. · pmid 27586814 · 2016

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.