Peptide Atlas · Cofactor

NAD+

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, central to energy metabolism, and an essential cofactor for enzymes such as sirtuins, CD38 and poly(ADP-ribose) polymerases.

emerging

provisional
PubChem 5892
2 citations
0 discussions
0 followers

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What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for NAD+. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Review: NAD+ metabolism and its roles during ageing	emerging	pmid 33353981
Review: NAD+ and sirtuins in ageing and disease	preclinical	pmid 24786309

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.