Peptide Atlas · Excipient

Polysorbate 20

Polysorbate 20 is a surfactant common in biopharmaceuticals; in two antibody products stored 18 to 36 months at 2-8 C it degraded into free fatty acids that precipitated as particles.

preclinical

provisional
2 citations
0 discussions
0 followers
PS20
Polysorbate 20 (Sorbitan Monolaurate PEO20)

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Polysorbate 20. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Polysorbate 20 degradation: free fatty acids and particles	preclinical	pmid 26419339
Host cell protein promotes polysorbate 20 degradation	preclinical	pmid 27032893

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.