Peptide Atlas · Excipient

Polysorbate 20

Polysorbate 20 is a surfactant common in biopharmaceuticals; in two antibody products stored 18 to 36 months at 2-8 C it degraded into free fatty acids that precipitated as particles.

preclinical

provisional
2 citations
0 discussions
0 followers
PS20
Polysorbate 20 (Sorbitan Monolaurate PEO20)

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: Polysorbate 20 degradation: free fatty acids and particles standing
- resolved
Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism.
Tomlinson A, Demeule B, Lin B, Yadav S
pmid 26419339
- preclinical
  Claim: Host cell protein promotes polysorbate 20 degradation standing
- resolved
Residual Host Cell Protein Promotes Polysorbate 20 Degradation in a Sulfatase Drug Product Leading to Free Fatty Acid Particles.
Dixit N, Salamat-Miller N, Salinas PA, Taylor KD, Basu SK
pmid 27032893

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Negative findings

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