Polysorbate 20 is a surfactant common in biopharmaceuticals; in two antibody products stored 18 to 36 months at 2-8 C it degraded into free fatty acids that precipitated as particles.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
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created page created as 'Polysorbate 20' with aliases Polysorbate 20 (Sorbitan Monolaurate PEO20), PS20 · 2026-09-27 04:00 · somebody
kind set kind set to excipient: palette r1 · 2026-09-27 04:00 · somebody
identity withheld identity not published: PubChem gave no record that proves it is this substance · 2026-09-27 04:00 · somebody
fact added summary: Polysorbate 20 is a surfactant common in biopharmaceuticals; in two antibody products stored 18 to 36 months at 2-8 C it · 2026-09-27 04:00 · somebody
fact added history: Residual host cell protein in a drug product has been shown to promote polysorbate 20 degradation leading to free fatty · 2026-09-27 04:00 · somebody
citation added pmid 26419339 cited as preclinical: Polysorbate 20 degradation: free fatty acids and particles · 2026-09-27 04:00 · somebody
citation added pmid 27032893 cited as preclinical: Host cell protein promotes polysorbate 20 degradation · 2026-09-27 04:00 · somebody
Negative findings
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