PTD-DBM (protein transduction domain fused to a Dishevelled-binding motif) is a competitor peptide that blocks the interaction of CXXC5 with Dishevelled, a negative feedback brake on Wnt/beta-catenin signalling.
preclinical
provisional
1 citation
0 discussions
0 followers
CXXC5 inhibitor peptide
Protein Transduction Domain-Dishevelled Binding Motif
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.
Summary
PTD-DBM (protein transduction domain fused to a Dishevelled-binding motif) is a competitor peptide that blocks the interaction of CXXC5 with Dishevelled, a negative feedback brake on Wnt/beta-catenin signalling. · pmid:26056233
Mechanism
It activated beta-catenin and collagen production in vitro, and mice lacking CXXC5 showed accelerated cutaneous wound healing. · pmid:26056233
Identity
No public registry record is shown for this page: PubChem gave no record that proves it is this substance.
Where the evidence actually sits
Preclinical only100%
Proportion of the 1 claim about PTD-DBM standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for PTD-DBM yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. · pmid 26056233 · 2015
1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.