Peptide Atlas · Cofactor

Pyrroloquinoline quinone disodium salt (PQQ / methoxatin)

In a small crossover study in 10 adults, oral PQQ lowered plasma C-reactive protein and interleukin-6 and shifted urinary metabolites in a way consistent with enhanced mitochondrial function; standard clinical measures were unchanged.

emerging

provisional
PubChem 1024
2 citations
0 discussions
0 followers
BioPQQ
PQQ
PQQ disodium salt
methoxatin
pyrroloquinoline quinone Na2

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What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- emerging
  Claim: Dietary PQQ lowered inflammation markers in 10 human subjects standing
- resolved
Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects.
Harris CB, Chowanadisai W, Mishchuk DO, Satre MA, Slupsky CM, Rucker RB
pmid 24231099
- preclinical
  Claim: PQQ stimulates mitochondrial biogenesis via CREB and PGC-1alpha in mouse hepatocytes standing
- resolved
Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression.
Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB
pmid 19861415

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Negative findings

failure is information

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