In a three-month randomized trial in 55 people with migraine, high-dose riboflavin (400 mg a day) reduced attack frequency and headache days more than placebo, with 59% responders against 15%.
emerging — human data exists, and it is thin or contested
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created page created as 'Riboflavin' with aliases Vitamin B2, Lactoflavin, Vitamin G, 7,8-dimethyl-10-ribitylisoalloxazine · 2026-09-27 12:04 · somebody
kind set kind set to vitamin: palette r2 · 2026-09-27 12:04 · somebody
fact added summary: In a three-month randomized trial in 55 people with migraine, high-dose riboflavin (400 mg a day) reduced attack frequen · 2026-09-27 12:04 · somebody
fact added mechanism: Riboflavin activated by ultraviolet-A light cross-links corneal collagen; treated human corneas became markedly stiffer, · 2026-09-27 12:04 · somebody
citation added pmid 9484373 cited as emerging: High-dose riboflavin for migraine prophylaxis (RCT, n=55) · 2026-09-27 12:04 · somebody
citation added pmid 14522301 cited as preclinical: Riboflavin-UVA cross-linking increases corneal rigidity (ex vivo) · 2026-09-27 12:04 · somebody
Negative findings
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