In a three-month randomized trial in 55 people with migraine, high-dose riboflavin (400 mg a day) reduced attack frequency and headache days more than placebo, with 59% responders against 15%.
emerging — human data exists, and it is thin or contested
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
In a three-month randomized trial in 55 people with migraine, high-dose riboflavin (400 mg a day) reduced attack frequency and headache days more than placebo, with 59% responders against 15%. · pmid:9484373
Mechanism
Riboflavin activated by ultraviolet-A light cross-links corneal collagen; treated human corneas became markedly stiffer, the basis of corneal cross-linking for keratoconus. · pmid:14522301
Proportion of the 2 claims about Riboflavin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Riboflavin yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. · pmid 9484373 · 1998
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. · pmid 14522301 · 2003
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.