Selank

Summary

Selank is the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, reported to have prolonged anti-anxiety and nootropic effects. · pmid:30255741

Mechanism

In radioligand studies it acted as a positive allosteric modulator of GABA binding. · pmid:30255741

It dose-dependently inhibited the enzymatic breakdown of plasma enkephalin (IC50 15 micromolar), more potently than the peptidase inhibitors bacitracin and puromycin. · pmid:11550013

Identity

PubChem CID 11765600: Selank, C33H57N11O9, 751.9 g/mol. · pubchem:11765600

CAS registry number 129954-34-3. · pubchem:11765600

IUPAC name: (2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid. · pubchem:11765600

Where the evidence actually sits

Proportion of the 2 claims about Selank standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Selank yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. · pmid 11550013 · 2001
   • Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. · pmid 30255741 · 2018

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.