Peptide Atlas · Peptide

Setmelanotide

Setmelanotide is a melanocortin-4 receptor agonist, first approved in the United States for chronic weight management in patients aged 6 and older with obesity caused by POMC, PCSK1 or leptin receptor deficiency.

established

provisional
PubChem 11993702
1 citation
0 discussions
0 followers
BIM-22493
Imcivree
MC4R agonist
RM-493
Setmelanotide acetate

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Setmelanotide. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Setmelanotide: first approval for obesity due to POMC, PCSK1 or LEPR deficiency	established	pmid 33638809

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.