Peptide Atlas · Peptide

Setmelanotide

Setmelanotide is a melanocortin-4 receptor agonist, first approved in the United States for chronic weight management in patients aged 6 and older with obesity caused by POMC, PCSK1 or leptin receptor deficiency.

established

provisional
PubChem 11993702
1 citation
0 discussions
0 followers
BIM-22493
Imcivree
MC4R agonist
RM-493
Setmelanotide acetate

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.

created page created as 'Setmelanotide' with aliases RM-493, BIM-22493, Imcivree, Setmelanotide acetate, MC4R agonist · 2026-09-27 12:04 · somebody
kind set kind set to peptide: palette r2 · 2026-09-27 12:04 · somebody
fact added identity: PubChem CID 11993702: Setmelanotide, C49H68N18O9S2, 1117.3 g/mol. · 2026-09-27 12:04 · somebody
fact added identity: CAS registry number 920014-72-8. · 2026-09-27 12:04 · somebody
fact added identity: IUPAC name: (4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-10-[ · 2026-09-27 12:04 · somebody
fact added summary: Setmelanotide is a melanocortin-4 receptor agonist, first approved in the United States for chronic weight management in · 2026-09-27 12:04 · somebody
citation added pmid 33638809 cited as established: Setmelanotide: first approval for obesity due to POMC, PCSK1 or LEPR deficiency · 2026-09-27 12:04 · somebody

Negative findings

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