Thiamine is an essential micronutrient central to energy metabolism; populations relying on milled or washed staple grains are at risk of deficiency, which contributes to infant mortality through infantile beriberi.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Thiamine is an essential micronutrient central to energy metabolism; populations relying on milled or washed staple grains are at risk of deficiency, which contributes to infant mortality through infantile beriberi. · pmid:30151974
In the VICTAS trial of 501 patients with sepsis, intravenous vitamin C, thiamine and hydrocortisone did not increase ventilator- and vasopressor-free days compared with placebo; the trial stopped early for administrative reasons. · pmid:33620405
Proportion of the 2 claims about Thiamine hydrochloride standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thiamine hydrochloride yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. · pmid 30151974 · 2018
Observational evidence· resolved human data at the emerging tier: thin, or contested
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. · pmid 33620405 · 2021
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.