Thymogen (Glu-Trp, EW)

Classification

Thymogen is the dipeptide L-Glu-L-Trp, an immunostimulant; its enantiomer D-Glu(D-Trp), thymodepressin, acts as an immunosuppressor, one of the first examples of opposite effects from two enantiomeric peptide drugs. · pmid:38732260

Mechanism

In an in vitro model of inflammation, alpha-glutamyl-tryptophan reduced TNF-alpha-induced IL-1-alpha production in endothelial cells and IL-8 secretion in blood mononuclear cells. · pmid:37131521

Identity

PubChem CID 100094: Thymogen, C16H19N3O5, 333.34 g/mol. · pubchem:100094

CAS registry number 38101-59-6, 122933-59-9. · pubchem:100094

IUPAC name: (4S)-4-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid. · pubchem:100094

Where the evidence actually sits

Proportion of the 2 claims about Thymogen (Glu-Trp, EW) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thymogen (Glu-Trp, EW) yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • The Effect of Drugs with α-Glutamyl-Tryptophan for Cytokine Secretion and Level of Surface Molecule ICAM-1 In Vitro. · pmid 37131521 · 2023
   • The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples. · pmid 38732260 · 2024

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.