Thymopoietin II, isolated from bovine thymus as a hormone that drives T-cell differentiation, is a single polypeptide chain of 49 amino acids with a mass of 5,562 daltons.
emerging — human data exists, and it is thin or contested
every claim resolves to its source
All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Thymopoietin II, isolated from bovine thymus as a hormone that drives T-cell differentiation, is a single polypeptide chain of 49 amino acids with a mass of 5,562 daltons. · pmid:1171728
Classification
The human gene named thymopoietin (TMPO) also encodes the nuclear lamina-associated polypeptide 2 (LAP2) isoforms; a LAP2-alpha mutation was found in one family with dilated cardiomyopathy. · pmid:16247757
Mechanism
A synthetic pentapeptide matching thymopoietin residues 32 to 36 (Arg-Lys-Asp-Val-Tyr) reproduced the parent molecule's actions on murine prothymocytes and B-lineage cells in vitro and in athymic mice. · pmid:451537
Identity
No public registry record is shown for this page: PubChem gave no record that proves it is this substance.
Where the evidence actually sits
Emerging33%
Preclinical only67%
Proportion of the 3 claims about Thymopoietin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thymopoietin yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
The amino acid sequence of thymopoietin II. · pmid 1171728 · 1975
A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin. · pmid 451537 · 1979
3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.