Thymosin beta 4 is an acidic, heat-stable peptide of about 5 kDa, first isolated from calf thymus, identical to Fx, the peptide that holds much of the unpolymerized actin in human platelets.
fact added identity: CAS registry number 77591-33-4. · 2026-09-27 04:00 · somebody
fact added summary: Thymosin beta 4 is an acidic, heat-stable peptide of about 5 kDa, first isolated from calf thymus, identical to Fx, the · 2026-09-27 04:00 · somebody
fact added mechanism: It forms a 1:1 complex with actin monomers and inhibits their polymerization. · 2026-09-27 04:00 · somebody
fact added history: After coronary artery ligation in mice, it activated integrin-linked kinase and Akt, enhanced early cardiomyocyte surviv · 2026-09-27 04:00 · somebody
citation added pmid 1999398 cited as preclinical: Thymosin beta 4 is the actin-sequestering peptide Fx · 2026-09-27 04:00 · somebody
citation added pmid 15565145 cited as preclinical: Thymosin beta 4 promotes cardiac cell migration, survival and repair in mice · 2026-09-27 04:00 · somebody
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