Thymosin beta 4 is an acidic, heat-stable peptide of about 5 kDa, first isolated from calf thymus, identical to Fx, the peptide that holds much of the unpolymerized actin in human platelets.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Thymosin beta 4 is an acidic, heat-stable peptide of about 5 kDa, first isolated from calf thymus, identical to Fx, the peptide that holds much of the unpolymerized actin in human platelets. · pmid:1999398
Mechanism
It forms a 1:1 complex with actin monomers and inhibits their polymerization. · pmid:1999398
History
After coronary artery ligation in mice, it activated integrin-linked kinase and Akt, enhanced early cardiomyocyte survival and improved cardiac function. · pmid:15565145
Proportion of the 2 claims about Thymosin Beta-4 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thymosin Beta-4 yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. · pmid 15565145 · 2004
Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. · pmid 1999398 · 1991
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.