Peptide Atlas · Salt form

Trifluoroacetate salt

Most synthetic peptides are made by solid-phase synthesis, whose cleavage and purification steps leave cationic peptides as trifluoroacetate salts.

preclinical

What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

created page created as 'Trifluoroacetate salt' with aliases TFA salt · 2026-09-27 04:00 · somebody
kind set kind set to salt_form: palette r1 · 2026-09-27 04:00 · somebody
fact added identity: Counterion: Trifluoroacetic acid, C2HF3O2, 114.02 g/mol (PubChem CID 6422). · 2026-09-27 04:00 · somebody
fact added identity: IUPAC name: 2,2,2-trifluoroacetic acid. · 2026-09-27 04:00 · somebody
fact added summary: Most synthetic peptides are made by solid-phase synthesis, whose cleavage and purification steps leave cationic peptides · 2026-09-27 04:00 · somebody
fact added history: Numerous studies report negative effects of trifluoroacetate salts in biological assays, and the counterion is commonly · 2026-09-27 04:00 · somebody
fact added mechanism: The classical exchange, freeze-drying several times with excess hydrochloric acid, works below pH 1 and can degrade the · 2026-09-27 04:00 · somebody
citation added pmid 18035848 cited as preclinical: Elimination and exchange of the trifluoroacetate counter-ion from peptides · 2026-09-27 04:00 · somebody
citation added pmid 40872554 cited as preclinical: Consensus on analysis and exchange of TFA counterions in synthetic peptides · 2026-09-27 04:00 · somebody

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