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Research

5-Amino-1MQ — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

5-Amino-1MQ belongs to a series of methylquinolinium small-molecule inhibitors of nicotinamide N-methyltransferase (NNMT), reported to be membrane-permeable and selective against related methyltransferases; it is a small molecule, not a peptide. · pmid:29155147

Mechanism

In cultured adipocytes these inhibitors lowered the NNMT product 1-methylnicotinamide, raised intracellular NAD+ and suppressed lipogenesis; in diet-induced obese mice a potent member of the series reduced body weight and white adipose mass. · pmid:29155147

In 24-month-old mice after an acute muscle injury, an NNMT inhibitor increased muscle stem cell proliferation and fusion. · pmid:30753815

Identity

No public registry record is shown for this page: PubChem gave no record that proves it is this substance.

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about 5-Amino-1MQ standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. (2018) · preclinicalSmall molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. (2019) · preclinical20182019

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for 5-Amino-1MQ yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. · pmid 29155147 · 2018
    • Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. · pmid 30753815 · 2019

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.