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Research

D-Sorbitol — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Sorbitol is a sugar alcohol used to stabilize proteins; it raised the melting temperature of ribonuclease A through preferential interactions that favour the native state. · pmid:9007993

Mechanism

In frozen storage at -30 C, sorbitol crystallized in a protein formulation and the protein aggregated; the sorbitol formulation's glass transition was near -45 C against -32 C for sucrose. · pmid:17109212

Identity

PubChem CID 5780: Sorbitol, C6H14O6, 182.17 g/mol. · pubchem:5780

CAS registry number 50-70-4. · pubchem:5780

IUPAC name: (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol. · pubchem:5780

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about D-Sorbitol standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Mechanism of the stabilization of ribonuclease A by sorbitol: preferential hydration is greater for the denatured then for the native protein. (1997) · preclinicalSorbitol crystallization can lead to protein aggregation in frozen protein formulations. (2007) · preclinical19972007

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for D-Sorbitol yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Sorbitol crystallization can lead to protein aggregation in frozen protein formulations. · pmid 17109212 · 2007
    • Mechanism of the stabilization of ribonuclease A by sorbitol: preferential hydration is greater for the denatured then for the native protein. · pmid 9007993 · 1997

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.