Peptide Atlas · Excipient

D-Sorbitol

Sorbitol is a sugar alcohol used to stabilize proteins; it raised the melting temperature of ribonuclease A through preferential interactions that favour the native state.

preclinical

provisional
PubChem 5780
2 citations
0 discussions
0 followers
D-Sorbitol (D-Glucitol)
Sorbitol

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for D-Sorbitol. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Sorbitol crystallization and protein aggregation in frozen formulations	preclinical	pmid 17109212
Mechanism of ribonuclease A stabilization by sorbitol	preclinical	pmid 9007993

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.