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Research

EDTA-2Na — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Edetate disodium (EDTA) is a chelating agent; in a monoclonal antibody formulation it mitigated both polysorbate 80 loss and methionine oxidation, proposed to act by chelating calcium and so reducing lipase activity. · pmid:30502482

Mechanism

A study of three antibody proteins found residue-specific effects of EDTA and methionine on oxidation under iron and peroxide stress. · pmid:36130676

Identity

PubChem CID 44120005: Edta disodium, C10H18N2Na2O10, 372.24 g/mol. · pubchem:44120005

CAS registry number 6381-92-6. · pubchem:44120005

IUPAC name: disodium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate;dihydrate. · pubchem:44120005

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about EDTA-2Na standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Edetate Disodium as a Polysorbate Degradation and Monoclonal Antibody Oxidation Stabilizer. (2019) · preclinicalResidue-Specific Impact of EDTA and Methionine on Protein Oxidation in Biotherapeutics Formulations Using an Integrated Biotherapeutics Drug Product Development Workflow. (2023) · preclinical20192023

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for EDTA-2Na yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Edetate Disodium as a Polysorbate Degradation and Monoclonal Antibody Oxidation Stabilizer. · pmid 30502482 · 2019
    • Residue-Specific Impact of EDTA and Methionine on Protein Oxidation in Biotherapeutics Formulations Using an Integrated Biotherapeutics Drug Product Development Workflow. · pmid 36130676 · 2023

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.