Peptide Atlas · Excipient

EDTA-2Na

Edetate disodium (EDTA) is a chelating agent; in a monoclonal antibody formulation it mitigated both polysorbate 80 loss and methionine oxidation, proposed to act by chelating calcium and so reducing lipase activity.

preclinical

provisional
PubChem 44120005
2 citations
0 discussions
0 followers
Disodium EDTA dihydrate
EDTA

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for EDTA-2Na. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Edetate disodium as a polysorbate degradation and antibody oxidation stabilizer	preclinical	pmid 30502482
Residue-specific impact of EDTA and methionine on protein oxidation	preclinical	pmid 36130676

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.