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Research

Folic acid — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

In a public-health programme in China covering about 248,000 pregnancies, 400 micrograms of folic acid a day around conception cut neural-tube defects by up to 85% in the northern high-risk region. · pmid:10559448

After mandatory folic acid fortification of cereal products in Canada, neural-tube defects fell by 46%, from 1.58 to 0.86 per 1,000 births. · pmid:17625125

Identity

PubChem CID 135398658: Folic Acid, C19H19N7O6, 441.4 g/mol. · pubchem:135398658

CAS registry number 59-30-3. · pubchem:135398658

IUPAC name: (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid. · pubchem:135398658

Where the evidence actually sits

Established100%

Proportion of the 2 claims about Folic acid standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. (1999) · establishedReduction in neural-tube defects after folic acid fortification in Canada. (2007) · established19992007

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Folic acid yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. · pmid 10559448 · 1999
    • Reduction in neural-tube defects after folic acid fortification in Canada. · pmid 17625125 · 2007
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.