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Research

HNG (S14G-Humanin / Glycine-Humanin) — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

S14G-humanin (HNG) is a derivative of the 24-residue peptide humanin with glycine in place of serine 14, about 1,000 times more potent than humanin at suppressing neuronal death caused by Alzheimer's-related insults in cell studies. · pmid:16945331

Mechanism

Injected into the brain ventricles of mice, S14G-humanin prevented amyloid-beta-induced memory impairment and preserved cholinergic neurons in the basal forebrain. · pmid:15678515

Identity

PubChem CID 155887372: H-Maprgfsclllltgeidlpvkrra-OH, C118H202N34O31S2, 2657.2 g/mol. · pubchem:155887372

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about HNG (S14G-Humanin / Glycine-Humanin) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice. (2005) · preclinicalSolution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease. (2006) · preclinical20052006

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for HNG (S14G-Humanin / Glycine-Humanin) yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice. · pmid 15678515 · 2005
    • Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease. · pmid 16945331 · 2006

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.