Peptide Atlas · Peptide

HNG (S14G-Humanin / Glycine-Humanin)

S14G-humanin (HNG) is a derivative of the 24-residue peptide humanin with glycine in place of serine 14, about 1,000 times more potent than humanin at suppressing neuronal death caused by Alzheimer's-related insults in cell studies.

preclinical

provisional
PubChem 155887372
2 citations
0 discussions
0 followers
HNG
Humanin G
S14G-Humanin
[Gly14]-Humanin

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for HNG (S14G-Humanin / Glycine-Humanin). Tier reflects study design, not enthusiasm.
Claim	Tier	Source
S14G-humanin prevented amyloid-beta-induced memory impairment in mice	preclinical	pmid 15678515
Solution structure of S14G-humanin, a 1000-fold more potent humanin derivative	preclinical	pmid 16945331

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.