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Research

N-Acetylcysteine (NAC) — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

N-acetylcysteine is the antidote for acetaminophen (paracetamol) overdose: in a multicenter study of 2,540 patients treated orally, liver injury was least when treatment began within 8 to 10 hours of ingestion, and efficacy fell with further delay. · pmid:3059186

A systematic review found favourable trial evidence for N-acetylcysteine in several psychiatric and neurological disorders, and called for larger controlled trials. · pmid:25957927

Identity

PubChem CID 12035: N-Acetyl-L-Cysteine, C5H9NO3S, 163.20 g/mol. · pubchem:12035

CAS registry number 616-91-1. · pubchem:12035

IUPAC name: (2R)-2-acetamido-3-sulfanylpropanoic acid. · pubchem:12035

Where the evidence actually sits

Established50%
Emerging50%

Proportion of the 2 claims about N-Acetylcysteine (NAC) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). (1988) · establishedClinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. (2015) · emerging19882015

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for N-Acetylcysteine (NAC) yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). · pmid 3059186 · 1988
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. · pmid 25957927 · 2015
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.