Peptide Atlas · Small molecule

N-Acetylcysteine (NAC)

N-acetylcysteine is the antidote for acetaminophen (paracetamol) overdose: in a multicenter study of 2,540 patients treated orally, liver injury was least when treatment began within 8 to 10 hours of ingestion, and efficacy fell with further delay.

established

provisional
PubChem 12035
2 citations
0 discussions
0 followers
N-acetyl-3-mercapto-L-alanine
N-acetyl-L-cysteine
NAC
acetylcysteine

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for N-Acetylcysteine (NAC). Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Systematic review of N-acetylcysteine trials in psychiatry and neurology	emerging	pmid 25957927
Oral N-acetylcysteine protects against acetaminophen hepatotoxicity when started early	established	pmid 3059186

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.