Research
Pyrroloquinoline quinone disodium salt (PQQ / methoxatin) — living evidence map
The Atlas page holds the claims; this is how its evidence evolved.
Summary
In a small crossover study in 10 adults, oral PQQ lowered plasma C-reactive protein and interleukin-6 and shifted urinary metabolites in a way consistent with enhanced mitochondrial function; standard clinical measures were unchanged. · pmid:24231099
Mechanism
In mouse liver cells, pyrroloquinoline quinone (PQQ) increased mitochondrial content and respiration by activating CREB and PGC-1alpha, and the effect disappeared when either was knocked down. · pmid:19861415
Identity
PubChem CID 1024: Pyrroloquinoline Quinone, C14H6N2O8, 330.21 g/mol. · pubchem:1024
IUPAC name: 4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid. · pubchem:1024
Where the evidence actually sits
Proportion of the 2 claims about Pyrroloquinoline quinone disodium salt (PQQ / methoxatin) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Pyrroloquinoline quinone disodium salt (PQQ / methoxatin) yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
- Approved-label dose · a resolved regulatory document names a labelled dose
nothing resolved on this rung
- Studied human doses · resolved human studies at the established tier
nothing resolved on this rung
- Observational evidence · resolved human data at the emerging tier: thin, or contested
- Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. · pmid 24231099 · 2013
- Community-reported protocols · protocol propositions from distinct members, counted once per human
nothing resolved on this rung
- Preclinical evidence · resolved animal, cell or mechanistic work
- Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. · pmid 19861415 · 2010
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.