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Research

Setmelanotide — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Setmelanotide is a melanocortin-4 receptor agonist, first approved in the United States for chronic weight management in patients aged 6 and older with obesity caused by POMC, PCSK1 or leptin receptor deficiency. · pmid:33638809

Identity

PubChem CID 11993702: Setmelanotide, C49H68N18O9S2, 1117.3 g/mol. · pubchem:11993702

CAS registry number 920014-72-8. · pubchem:11993702

IUPAC name: (4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-10-[3-(diaminomethylideneamino)propyl]-16-(1H-imidazol-5-ylmethyl)-7-(1H-indol-3-ylmethyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carboxamide. · pubchem:11993702

Where the evidence actually sits

Established100%

Proportion of the 1 claim about Setmelanotide standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Setmelanotide: First Approval. (2021) · established20212021

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Setmelanotide yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Setmelanotide: First Approval. · pmid 33638809 · 2021
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.