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Research

Sodium chloride (injectable carrier/electrolyte) — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

In the BaSICS trial of 10,520 critically ill patients, a balanced solution did not lower 90-day mortality compared with 0.9% sodium chloride (26.4% against 27.2%). · pmid:34375394

An individual-patient meta-analysis of six trials (34,685 intensive-care patients) found in-hospital mortality of 16.8% with balanced solutions and 17.3% with 0.9% saline, while in traumatic brain injury mortality was higher with balanced solutions. · pmid:38043564

Identity

PubChem CID 5234: Sodium Chloride, ClNa, 58.44 g/mol. · pubchem:5234

IUPAC name: sodium chloride. · pubchem:5234

Where the evidence actually sits

Established100%

Proportion of the 2 claims about Sodium chloride (injectable carrier/electrolyte) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial. (2021) · establishedBalanced crystalloids versus saline for critically ill patients (BEST-Living): a systematic review and individual patient data meta-analysis. (2024) · established20212024

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Sodium chloride (injectable carrier/electrolyte) yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial. · pmid 34375394 · 2021
    • Balanced crystalloids versus saline for critically ill patients (BEST-Living): a systematic review and individual patient data meta-analysis. · pmid 38043564 · 2024
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.