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Research

Thymopoietin — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Thymopoietin II, isolated from bovine thymus as a hormone that drives T-cell differentiation, is a single polypeptide chain of 49 amino acids with a mass of 5,562 daltons. · pmid:1171728

Classification

The human gene named thymopoietin (TMPO) also encodes the nuclear lamina-associated polypeptide 2 (LAP2) isoforms; a LAP2-alpha mutation was found in one family with dilated cardiomyopathy. · pmid:16247757

Mechanism

A synthetic pentapeptide matching thymopoietin residues 32 to 36 (Arg-Lys-Asp-Val-Tyr) reproduced the parent molecule's actions on murine prothymocytes and B-lineage cells in vitro and in athymic mice. · pmid:451537

Identity

No public registry record is shown for this page: PubChem gave no record that proves it is this substance.

Where the evidence actually sits

Emerging33%
Preclinical only67%

Proportion of the 3 claims about Thymopoietin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

The amino acid sequence of thymopoietin II. (1975) · preclinicalA synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin. (1979) · preclinicalThymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. (2005) · emerging19752005

3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thymopoietin yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. · pmid 16247757 · 2005
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • The amino acid sequence of thymopoietin II. · pmid 1171728 · 1975
    • A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin. · pmid 451537 · 1979

3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.