Adenosylcobalamin is one of the two coenzyme forms of vitamin B12 (cobalamin), one of the most structurally complex small molecules made in nature; its full biosynthesis from uroporphyrinogen III has been worked out.
emerging — human data exists, and it is thin or contested
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Adenosylcobalamin is one of the two coenzyme forms of vitamin B12 (cobalamin), one of the most structurally complex small molecules made in nature; its full biosynthesis from uroporphyrinogen III has been worked out. · pmid:12195810
Mechanism
Adenosylcobalamin is the coenzyme of the mitochondrial enzyme methylmalonyl-CoA mutase; in a child with the cblB form of methylmalonic acidaemia, intramuscular adenosylcobalamin raised serum cobalamin greatly but lowered methylmalonic acid excretion only briefly. · pmid:6434828
Proportion of the 2 claims about Adenosylcobalamin (Vitamin B12, coenzyme B12) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Adenosylcobalamin (Vitamin B12, coenzyme B12) yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
Treatment of the cbl B form of methylmalonic acidaemia with adenosylcobalamin. · pmid 6434828 · 1984
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
The biosynthesis of adenosylcobalamin (vitamin B12). · pmid 12195810 · 2002
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.