Peptide Atlas · Excipient

Benzyl Alcohol

Benzyl alcohol is an antimicrobial preservative; it accelerated the aggregation and precipitation of recombinant interleukin-1 receptor antagonist by shifting the protein toward partially unfolded forms.

established

provisional
PubChem 244
3 citations
0 discussions
0 followers
Benzyl Alcohol (Phenylmethanol)
BnOH

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- established
  Claim: Fatal benzyl alcohol poisoning in a neonatal intensive care unit (Lancet 1982) standing
- resolved
Fatal benzyl alcohol poisoning in a neonatal intensive care unit.
Brown WJ, Buist NR, Gipson HT, Huston RK, Kennaway NG
pmid 6123006
- established
  Claim: The gasping syndrome and benzyl alcohol poisoning (NEJM 1982) standing
- resolved
The gasping syndrome and benzyl alcohol poisoning.
Gershanik J, Boecler B, Ensley H, McCloskey S, George W
pmid 7133084
- preclinical
  Claim: Mechanism of benzyl alcohol-induced protein aggregation standing
- resolved
Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution.
Zhang Y, Roy S, Jones LS, Krishnan S, Kerwin BA, Chang BS, Manning MC, Randolph TW, Carpenter JF
pmid 15514986

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

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