Benzyl alcohol is an antimicrobial preservative; it accelerated the aggregation and precipitation of recombinant interleukin-1 receptor antagonist by shifting the protein toward partially unfolded forms.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Benzyl alcohol is an antimicrobial preservative; it accelerated the aggregation and precipitation of recombinant interleukin-1 receptor antagonist by shifting the protein toward partially unfolded forms. · pmid:15514986
History
In 1982 fatal benzyl alcohol poisoning was reported from a neonatal intensive care unit. · pmid:6123006
The same year, a gasping syndrome was described as benzyl alcohol poisoning. · pmid:7133084
Proportion of the 3 claims about Benzyl Alcohol standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Benzyl Alcohol yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Fatal benzyl alcohol poisoning in a neonatal intensive care unit. · pmid 6123006 · 1982
The gasping syndrome and benzyl alcohol poisoning. · pmid 7133084 · 1982
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution. · pmid 15514986 · 2004
3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.