Peptide Atlas · Excipient

D-Sorbitol

Sorbitol is a sugar alcohol used to stabilize proteins; it raised the melting temperature of ribonuclease A through preferential interactions that favour the native state.

preclinical

provisional
PubChem 5780
2 citations
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D-Sorbitol (D-Glucitol)
Sorbitol

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: Sorbitol crystallization and protein aggregation in frozen formulations standing
- resolved
Sorbitol crystallization can lead to protein aggregation in frozen protein formulations.
Piedmonte DM, Summers C, McAuley A, Karamujic L, Ratnaswamy G
pmid 17109212
- preclinical
  Claim: Mechanism of ribonuclease A stabilization by sorbitol standing
- resolved
Mechanism of the stabilization of ribonuclease A by sorbitol: preferential hydration is greater for the denatured then for the native protein.
Xie G, Timasheff SN
pmid 9007993

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

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