Peptide Atlas · Excipient

D-Sorbitol

Sorbitol is a sugar alcohol used to stabilize proteins; it raised the melting temperature of ribonuclease A through preferential interactions that favour the native state.

preclinical

provisional
PubChem 5780
2 citations
0 discussions
0 followers
D-Sorbitol (D-Glucitol)
Sorbitol

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

created page created as 'D-Sorbitol' with aliases D-Sorbitol (D-Glucitol), Sorbitol · 2026-09-27 04:00 · somebody
kind set kind set to excipient: palette r1 · 2026-09-27 04:00 · somebody
fact added identity: PubChem CID 5780: Sorbitol, C6H14O6, 182.17 g/mol. · 2026-09-27 04:00 · somebody
fact added identity: CAS registry number 50-70-4. · 2026-09-27 04:00 · somebody
fact added identity: IUPAC name: (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol. · 2026-09-27 04:00 · somebody
fact added summary: Sorbitol is a sugar alcohol used to stabilize proteins; it raised the melting temperature of ribonuclease A through pref · 2026-09-27 04:00 · somebody
fact added mechanism: In frozen storage at -30 C, sorbitol crystallized in a protein formulation and the protein aggregated; the sorbitol form · 2026-09-27 04:00 · somebody
citation added pmid 9007993 cited as preclinical: Mechanism of ribonuclease A stabilization by sorbitol · 2026-09-27 04:00 · somebody
citation added pmid 17109212 cited as preclinical: Sorbitol crystallization and protein aggregation in frozen formulations · 2026-09-27 04:00 · somebody

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.