Sorbitol is a sugar alcohol used to stabilize proteins; it raised the melting temperature of ribonuclease A through preferential interactions that favour the native state.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Sorbitol is a sugar alcohol used to stabilize proteins; it raised the melting temperature of ribonuclease A through preferential interactions that favour the native state. · pmid:9007993
Mechanism
In frozen storage at -30 C, sorbitol crystallized in a protein formulation and the protein aggregated; the sorbitol formulation's glass transition was near -45 C against -32 C for sucrose. · pmid:17109212
Proportion of the 2 claims about D-Sorbitol standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for D-Sorbitol yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Sorbitol crystallization can lead to protein aggregation in frozen protein formulations. · pmid 17109212 · 2007
Mechanism of the stabilization of ribonuclease A by sorbitol: preferential hydration is greater for the denatured then for the native protein. · pmid 9007993 · 1997
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.