Peptide Atlas · Excipient

EDTA-2Na

Edetate disodium (EDTA) is a chelating agent; in a monoclonal antibody formulation it mitigated both polysorbate 80 loss and methionine oxidation, proposed to act by chelating calcium and so reducing lipase activity.

preclinical

provisional
PubChem 44120005
2 citations
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Disodium EDTA dihydrate
EDTA

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

created page created as 'EDTA-2Na' with aliases Disodium EDTA dihydrate, EDTA · 2026-09-27 04:00 · somebody
kind set kind set to excipient: palette r1 · 2026-09-27 04:00 · somebody
fact added identity: PubChem CID 44120005: Edta disodium, C10H18N2Na2O10, 372.24 g/mol. · 2026-09-27 04:00 · somebody
fact added identity: CAS registry number 6381-92-6. · 2026-09-27 04:00 · somebody
fact added identity: IUPAC name: disodium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate;dihydrate. · 2026-09-27 04:00 · somebody
fact added summary: Edetate disodium (EDTA) is a chelating agent; in a monoclonal antibody formulation it mitigated both polysorbate 80 loss · 2026-09-27 04:00 · somebody
fact added mechanism: A study of three antibody proteins found residue-specific effects of EDTA and methionine on oxidation under iron and per · 2026-09-27 04:00 · somebody
citation added pmid 30502482 cited as preclinical: Edetate disodium as a polysorbate degradation and antibody oxidation stabilizer · 2026-09-27 04:00 · somebody
citation added pmid 36130676 cited as preclinical: Residue-specific impact of EDTA and methionine on protein oxidation · 2026-09-27 04:00 · somebody

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